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Details on Person Glucosamine-fructose 6-phosphate aminotransferases 1 and 2 (...
| Class:Id | Summation:449699 |
|---|---|
| _displayName | Glucosamine-fructose 6-phosphate aminotransferases 1 and 2 (... |
| _timestamp | 2015-04-30 09:40:48 |
| created | [InstanceEdit:449736] Jassal, B, 2009-12-07 |
| literatureReference | [LiteratureReference:1236605] Hexosamine biosynthetic pathway mutations cause neuromuscular transmission defect |
| modified | [InstanceEdit:771704] Jassal, B, 2010-05-21 [InstanceEdit:1236607] Jassal, B, 2011-03-28 [InstanceEdit:4085031] Jassal, Bijay, 2013-08-01 [InstanceEdit:5690643] Jassal, Bijay, 2015-04-30 |
| text | Glucosamine-fructose 6-phosphate aminotransferases 1 and 2 (GFPT1,2) are the first and rate-limiting enzymes in the hexosamine synthesis pathway, and thus formation of hexosamines like N-acetylglucosamine (GlcNAc). These enzymes probably play a role in limiting the availability of substrates for the N- and O- linked glycosylation of proteins (McKnight et al. 1992, Oki et al. 1999). GFPT1 and 2 are required for normal functioning of neuromuscular synaptic transmission. Defects in GFPT1 lead to altered muscle fibre morphology and impaired neuromuscular junction development (Senderek et al. 2011). |
| (summation) | [Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P [Homo sapiens] |
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No pathways have been reviewed or authored by Glucosamine-fructose 6-phosphate aminotransferases 1 and 2 (... (449699)
