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Details on Person MBC stimulates nucleotide exchange of RAC1:GDP complex

Class:IdReaction:449377
_displayNameMBC stimulates nucleotide exchange of RAC1:GDP complex
_doReleaseFALSE
_timestamp2017-06-27 17:36:25
authored[InstanceEdit:449430] Williams, MG, 2009-11-19
catalystActivity[CatalystActivity:449574] guanyl-nucleotide exchange factor activity of PVF dimer:Phospho PVR dimer:CRK:MBC:RAC1:GDP:CED-12 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:449425] Williams, MG, 2009-12-02
figure[Figure:449594] /figures/DrosPVRA20.jpg
input[Complex:449510] PVF dimer:Phospho PVR dimer:CRK:MBC:RAC1:GDP:CED-12 [plasma membrane] [Drosophila melanogaster]
[SimpleEntity:29438] GTP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:449543] PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis
[LiteratureReference:449539] Activation of Rac1 by a Crk SH3-binding protein, DOCK180
[LiteratureReference:449620] Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity
modified[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
nameMBC stimulates nucleotide exchange of RAC1:GDP complex
output[Complex:449615] PVF dimer:Phospho PVR dimer:CRK:MBC:RAC1:GTP:CED-12 [plasma membrane] [Drosophila melanogaster]
[SimpleEntity:29420] GDP [cytosol]
precedingEvent
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8925703] R-DME-449377.1
summation[Summation:449571] The DOCK180 orthologue, myoblast city (MBC) functions as a g...
(hasEvent)[Pathway:449471] Rac GTPase cycle (PVR) [Drosophila melanogaster]
(precedingEvent)[Reaction:449552] MBC dissociates from RAC1:GTP complex [Drosophila melanogaster]
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No pathways have been reviewed or authored by MBC stimulates nucleotide exchange of RAC1:GDP complex (449377)
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