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Details on Person Phosphorylation of PIP2 to PIP3 by PI3K92E:PI3K21B complex (PVR)

Class:Id	Reaction:449374
_displayName	Phosphorylation of PIP2 to PIP3 by PI3K92E:PI3K21B complex (PVR)
_doRelease	FALSE
_timestamp	2017-06-27 17:37:42
authored	[InstanceEdit:449430] Williams, MG, 2009-11-19
catalystActivity	[CatalystActivity:449498] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PVF dimer:Phospho PVR dimer:PI3K92E:PI3K21B [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:449425] Williams, MG, 2009-12-02
figure	[Figure:449490] /figures/DrosPVRA15.jpg
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:376987] The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
modified	[InstanceEdit:480995] Williams, MG, 2010-01-27 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
name	Phosphorylation of PIP2 to PIP3 by PI3K92E:PI3K21B complex (PVR)
output	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:449494] PI3K92E:PI3K21B complex binds to phosphorylated PVR [Drosophila melanogaster] [Reaction:449527] PVR dimer complex autophosphorylates [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8929986] R-DME-449374.1
summation	[Summation:377379] The PI3K kinase (PI3K21B) phosphorylates phosphatidylinosito...
(hasEvent)	[Pathway:449467] Activation of PI3K complex [Drosophila melanogaster]
(precedingEvent)	[Reaction:377065] PTEN dephosphorylates PIP3 to PIP2 [Drosophila melanogaster] [Reaction:377364] AKT1 and PK61C are recruited by PIP3 to the plasma membrane [Drosophila melanogaster]
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No pathways have been reviewed or authored by Phosphorylation of PIP2 to PIP3 by PI3K92E:PI3K21B complex (PVR) (449374)