Query author contributions in Reactome
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Details on Person The sixth mannose is added to the N-glycan precursor. This r...
| Class:Id | Summation:449261 |
|---|---|
| _displayName | The sixth mannose is added to the N-glycan precursor. This r... |
| _timestamp | 2013-10-21 15:23:03 |
| created | [InstanceEdit:449318] Jassal, B, 2009-12-02 |
| modified | [InstanceEdit:449893] Jassal, B, 2009-12-09 [InstanceEdit:604389] Jassal, B, 2010-04-16 [InstanceEdit:916859] Jassal, B, 2010-07-29 [InstanceEdit:4720494] Jassal, B, 2013-10-21 |
| text | The sixth mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses a different mannose donor (dolichyl-phosphate-mannose) than the previous steps. It has been proposed that ALG3, along with all the mannosyl- and glucosyltransferases in the N-glycan biosynthesis pathway that use dolichyl-phosphate-mannose or dolichyl-phosphate-glucose as donor, derive from duplications of a common ancestral enzyme (Oriol et al. 2002). Defects in ALG3 are associated with Congenital Disorder of Glycosylation 1D (CDG1D) (Sun et al. 2005). |
| (summation) | [Reaction:446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 [Homo sapiens] |
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No pathways have been reviewed or authored by The sixth mannose is added to the N-glycan precursor. This r... (449261)
