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Details on Person N-linked glycosylation commences with the 14-step synthesis ...
| Class:Id | Summation:449250 |
|---|---|
| _displayName | N-linked glycosylation commences with the 14-step synthesis ... |
| _timestamp | 2013-06-28 13:01:44 |
| created | [InstanceEdit:449318] Jassal, B, 2009-12-02 |
| modified | [InstanceEdit:449736] Jassal, B, 2009-12-07 [InstanceEdit:452052] Jassal, B, 2010-01-15 [InstanceEdit:604389] Jassal, B, 2010-04-16 [InstanceEdit:763956] Jassal, B, 2010-05-20 [InstanceEdit:763957] Jassal, B, 2010-05-20 [InstanceEdit:771704] Jassal, B, 2010-05-21 [InstanceEdit:847667] D'Eustachio, P, 2010-05-29 [InstanceEdit:933769] Jassal, B, 2010-08-17 [InstanceEdit:3781827] Jassal, B, 2013-06-28 |
| text | N-linked glycosylation commences with the 14-step synthesis of a dolichol lipid-linked oligosaccharide (LLO) consisting of 14 sugars (2 core GlcNAcs, 9 mannoses and 3 terminal GlcNAcs). This pathway is highly conserved in eukaryotes, and a closely related pathway is found in many eubacteria and Archaea. Mutations in the genes associated with N-glycan precursor synthesis lead to a diverse group of disorders collectively known as Congenital Disorders of Glycosylation (type I and II) (Sparks et al. 1993). The phenotypes of these disorders reflect the important role that N-glycosylation has during development, controlling the folding and the properties of proteins in the secretory pathway, and proteins that mediate cell-to-cell interactions or timing of development. |
| (summation) | [Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein [Homo sapiens] |
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No pathways have been reviewed or authored by N-linked glycosylation commences with the 14-step synthesis ... (449250)
