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Details on Person The Interleukin-15 (IL15) / Interleukin-15 receptor subunit ...

Class:IdSummation:449141
_displayNameThe Interleukin-15 (IL15) / Interleukin-15 receptor subunit ...
_timestamp2017-08-07 15:30:43
created[InstanceEdit:449109] Jupe, S, 2009-11-27
literatureReference[LiteratureReference:9006754] Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
[LiteratureReference:449144] Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
[LiteratureReference:449142] Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes
[LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
modified[InstanceEdit:6804715] Jupe, Steve, 2015-10-14
[InstanceEdit:8850923] Jupe, Steve, 2016-01-04
[InstanceEdit:8854506] Jupe, Steve, 2016-01-27
[InstanceEdit:8983275] Duenas, Corina, 2017-03-23
[InstanceEdit:8983475] Jupe, Steve, 2017-03-24
[InstanceEdit:8983912] Duenas, Corina, 2017-03-31
[InstanceEdit:8984725] Jupe, Steve, 2017-04-10
[InstanceEdit:9006747] Jupe, Steve, 2017-05-18
[InstanceEdit:9006767] Jupe, Steve, 2017-05-19
[InstanceEdit:9007192] Duenas, Corina, 2017-05-26
[InstanceEdit:9009740] Duenas, Corina, 2017-06-22
[InstanceEdit:9009893] Duenas, Corina, 2017-06-23
[InstanceEdit:9010003] Duenas, Corina, 2017-06-26
[InstanceEdit:9011720] Jupe, Steve, 2017-07-05
[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
textThe Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the beta and gamma subunits pre-associate before binding IL15:IL15RA.
(summation)[BlackBoxEvent:449115] IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 [Homo sapiens]
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