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Details on Person IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

Class:IdBlackBoxEvent:449115
_displayNameIL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3
_doReleaseTRUE
_timestamp2017-08-21 15:30:21
authored[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:449109] Jupe, S, 2009-11-27
edited[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
[InstanceEdit:9015191] Duenas, Corina, 2017-08-09
input[Complex:8983124] IL15:IL15RA [plasma membrane] [Homo sapiens]
[Complex:451905] IL2RB:JAK1 [plasma membrane] [Homo sapiens]
[Complex:451911] IL2RG:JAK3 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:449144] Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
[LiteratureReference:449142] Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes
modified[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:2981011] Jassal, B, 2013-01-14
[InstanceEdit:2990819] Jassal, B, 2013-01-17
[InstanceEdit:6787775] Jupe, Steve, 2015-07-17
[InstanceEdit:8854506] Jupe, Steve, 2016-01-27
[InstanceEdit:8854754] Jupe, Steve, 2016-01-28
[InstanceEdit:8983277] Duenas, Corina, 2017-03-23
[InstanceEdit:8983475] Jupe, Steve, 2017-03-24
[InstanceEdit:8984725] Jupe, Steve, 2017-04-10
[InstanceEdit:9005910] Jupe, Steve, 2017-05-11
[InstanceEdit:9006766] Jupe, Steve, 2017-05-18
[InstanceEdit:9015193] Duenas, Corina, 2017-08-09
[InstanceEdit:9017396] Duenas, Corina, 2017-08-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameIL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3
output[Complex:449120] IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
[InstanceEdit:9014997] Patidar, Manoj, 2017-08-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8861459] R-HSA-449115.4
summation[Summation:449141] The Interleukin-15 (IL15) / Interleukin-15 receptor subunit ...
(hasEvent)[Pathway:8983432] Interleukin-15 signaling [Homo sapiens]
[Pathway:9664432] IL15RA pro-inflammatory induction [Homo sapiens]
(precedingEvent)[BlackBoxEvent:8983300] IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 [Homo sapiens]
[BlackBoxEvent:8983386] NORELEASE_NEED+EVIDENCE_IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 binds TYK2 [Homo sapiens]
[Reaction:8983392] SYK binds IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780760] Update Tracker - [BlackBoxEvent:449115] IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 - v62:[modifyText]
[_UpdateTracker:9781219] Update Tracker - [BlackBoxEvent:449115] IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 - v61:[add_removeInput, modifyText]
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No pathways have been reviewed or authored by IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (449115)
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