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Details on Person MyoD-E protein heterodimers interact with MEF2 proteins to s...
| Class:Id | Summation:448808 |
|---|---|
| _displayName | MyoD-E protein heterodimers interact with MEF2 proteins to s... |
| _timestamp | 2010-01-19 09:34:16 |
| created | [InstanceEdit:448806] Garapati, P V, 2009-11-26 |
| modified | [InstanceEdit:449212] Garapati, P V, 2009-12-02 [InstanceEdit:453163] Garapati, P V, 2010-01-19 |
| text | MyoD-E protein heterodimers interact with MEF2 proteins to synergistically activate myogenesis. This interaction occurs via association of these two heterologous classes of transcription factors through their DNA-binding and dimerization motifs. The combinatorial associations of these two protein families appear to establish a transcriptional code specific for skeletal muscle gene activation. Together with the Mef2 proteins and E proteins, MyoD transcription factors are responsible for coordinating muscle-specific gene expression in the undifferentiated myoblast. MyoD activation leads to expression of myogenin, M-cadherin, myosin heavy and light chains, and muscle creatine kinase. |
| (summation) | [Reaction:448963] Interaction of MyoD:E protein with MEF2 [Homo sapiens] |
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No pathways have been reviewed or authored by MyoD-E protein heterodimers interact with MEF2 proteins to s... (448808)
