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Details on Person IL19 binds IL20RA:JAK1:IL20RB

Class:Id	BlackBoxEvent:448728
_displayName	IL19 binds IL20RA:JAK1:IL20RB
_doRelease	TRUE
_timestamp	2017-11-15 09:04:30
authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:448729] Jupe, S, 2009-11-25
edited	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
input	[Complex:448724] IL20RA:JAK1:IL20RB [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:448456] IL19 [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions [LiteratureReference:8854681] Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines [LiteratureReference:9006696] Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10) [LiteratureReference:9006691] Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20
modified	[InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:6803161] Jupe, Steve, 2015-10-05 [InstanceEdit:6804715] Jupe, Steve, 2015-10-14 [InstanceEdit:8854660] Jupe, Steve, 2016-01-28 [InstanceEdit:8854754] Jupe, Steve, 2016-01-28 [InstanceEdit:8987444] Duenas, Corina, 2017-05-05 [InstanceEdit:9005363] Duenas, Corina, 2017-05-08 [InstanceEdit:9006701] Duenas, Corina, 2017-05-18 [InstanceEdit:9006768] Duenas, Corina, 2017-05-19 [InstanceEdit:9009145] Duenas, Corina, 2017-06-15 [InstanceEdit:9029253] Jupe, Steve, 2017-11-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL19 binds IL20RA:JAK1:IL20RB IL20RA:IL20RB binds IL19
output	[Complex:448743] IL19:IL20RA:JAK1:IL20RB [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:448744] IL20RA binds IL20RB [Homo sapiens] [BlackBoxEvent:8987039] JAK1 binds IL20RA [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861455] R-HSA-448728.5
summation	[Summation:8854698] Interleukin-19 (IL19) binds a heterodimeric receptor complex...
(hasEvent)	[Pathway:8854691] Interleukin-20 family signaling [Homo sapiens]
(precedingEvent)	[Pathway:5684996] MAPK1/MAPK3 signaling [Homo sapiens] [BlackBoxEvent:8987084] IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780533] Update Tracker - [BlackBoxEvent:448728] IL19 binds IL20RA:JAK1:IL20RB - v62:[modifyText] [_UpdateTracker:9781347] Update Tracker - [BlackBoxEvent:448728] IL19 binds IL20RA:JAK1:IL20RB - v61:[addLiteratureReference, add_removeInput, modifyText]
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No pathways have been reviewed or authored by IL19 binds IL20RA:JAK1:IL20RB (448728)