Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Interleukin-1 family precursors are cleaved by caspase-1

Class:Id	Reaction:448703
_displayName	Interleukin-1 family precursors are cleaved by caspase-1
_doRelease	TRUE
_timestamp	2020-01-07 13:34:11
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:448682] cysteine-type endopeptidase activity of Caspase-1 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:448681] Jupe, S, 2009-11-25
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
input	[CandidateSet:449039] Interleukin-1 family propeptides [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:448676] A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes [LiteratureReference:449064] Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme [LiteratureReference:449049] Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
modified	[InstanceEdit:448729] Jupe, S, 2009-11-25 [InstanceEdit:449061] Jupe, S, 2009-11-27 [InstanceEdit:507710] Jupe, S, 2010-02-08 [InstanceEdit:918243] Jupe, S, 2010-08-02 [InstanceEdit:926764] Jupe, S, 2010-08-06 [InstanceEdit:941864] Jupe, S, 2010-09-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9673428] Murillo, Julieth, 2020-01-07 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Interleukin-1 family precursors are cleaved by caspase-1
output	[CandidateSet:449063] Interleukin-1 family [cytosol] [Homo sapiens] [CandidateSet:449026] Interleukin-1 family N-terminal propeptides [cytosol] [Homo sapiens]
precedingEvent	[Reaction:448702] Caspase-1 active tetramer formation [Homo sapiens] [Reaction:448673] Formation of caspase-1 p10/p20 dimer [Homo sapiens]
regulatedBy	[PositiveRegulation:844659] Positive regulation by 'NFkB Complex [nucleoplasm]'
regulationReference	[RegulationReference:9642366] Positive regulation by 'NFkB Complex [nucleoplasm]' Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop
releaseDate	2010-09-21
reviewed	[InstanceEdit:941865] Pinteaux, E, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104904] R-HSA-448703.6
summation	[Summation:448679] Pro-interleukin-1 beta (pro-IL1B) is the primary substrate o... [Summation:844632] In the absence of TLR agonist 'priming', inflammasome depend...
(hasEvent)	[Pathway:448706] Interleukin-1 processing [Homo sapiens] [Pathway:9660826] Purinergic signaling in leishmaniasis infection [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:449058] Interleukin-1 family are secreted [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775559] Update Tracker - [Reaction:448703] Interleukin-1 family precursors are cleaved by caspase-1 - v78:[addSummation]
[Change default viewing format]

No pathways have been reviewed or authored by Interleukin-1 family precursors are cleaved by caspase-1 (448703)