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Details on Person Caspase-1 active tetramer formation

Class:Id	Reaction:448702
_displayName	Caspase-1 active tetramer formation
_doRelease	TRUE
_timestamp	2020-01-07 13:29:56
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:448681] Jupe, S, 2009-11-25
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
input	[Complex:448695] CASP1(120-197):CASP1(317-404) [cytosol] [Homo sapiens] [Complex:448695] CASP1(120-197):CASP1(317-404) [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:448701] Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer
modified	[InstanceEdit:448729] Jupe, S, 2009-11-25 [InstanceEdit:561112] Jupe, S, 2010-03-25 [InstanceEdit:918243] Jupe, S, 2010-08-02 [InstanceEdit:926764] Jupe, S, 2010-08-06 [InstanceEdit:941864] Jupe, S, 2010-09-06 [InstanceEdit:9673427] Murillo, Julieth, 2020-01-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-1 active tetramer formation
output	[Complex:448691] Caspase-1 tetramer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:448673] Formation of caspase-1 p10/p20 dimer [Homo sapiens] [Reaction:448678] CTSG cleaves CASP1(1-404) [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941865] Pinteaux, E, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105389] R-HSA-448702.3
summation	[Summation:561114] Two p10/p20 dimers associate to form the active tetramer
(hasEvent)	[Pathway:448706] Interleukin-1 processing [Homo sapiens] [Pathway:9660826] Purinergic signaling in leishmaniasis infection [Homo sapiens]
(precedingEvent)	[Reaction:448703] Interleukin-1 family precursors are cleaved by caspase-1 [Homo sapiens] [BlackBoxEvent:9647680] CASP1 cleaves GSDMD [Homo sapiens]
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No pathways have been reviewed or authored by Caspase-1 active tetramer formation (448702)