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Details on Person Caspase-1 tetramer [cytosol]

Class:Id	Complex:448691
_displayName	Caspase-1 tetramer [cytosol]
_timestamp	2017-10-20 15:25:35
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:448681] Jupe, S, 2009-11-25
hasComponent	[Complex:448695] CASP1(120-197):CASP1(317-404) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:448704] CASP1(317-404) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:448686] CASP1(120-297) [cytosol] [Homo sapiens] [Complex:448695] CASP1(120-197):CASP1(317-404) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:448704] CASP1(317-404) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:448686] CASP1(120-297) [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:448729] Jupe, S, 2009-11-25 [InstanceEdit:2022155] D'Eustachio, P, 2011-11-25 [InstanceEdit:9012590] Duenas, Corina, 2017-07-17 [InstanceEdit:9026564] Jupe, Steve, 2017-10-20
name	Caspase-1 tetramer 2x(CASP1(120-197):CASP1(317-404))
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1109117] R-HSA-448691.3
(hasComponent)	[Complex:9012502] IL18-2(1-36):IL18-2(37-189):2x(CASP1(120-197):CASP1(317-404)) [cytosol] [Homo sapiens] [Complex:9012505] IL18(1-36):IL18(37-193):Caspase-1 tetramer [cytosol] [Homo sapiens] [Complex:9012506] IL18-2:2x(CASP1(120-197):CASP1(317-404)) [cytosol] [Homo sapiens] [Complex:9012510] IL18(1-193):Caspase-1 tetramer [cytosol] [Homo sapiens] [Complex:9012553] IL37:2x(CASP1(120-197):CASP1(317-404)) [cytosol] [Homo sapiens] [Complex:9712413] NLRP3 oligomer:MAVS:TRAF3:K63polyUb-PYCARD oligomer:CASP1 [mitochondrial outer membrane] [Homo sapiens] [Complex:9731024] caspase-1 tetramer:O-glycosyl 3a [plasma membrane] [Homo sapiens]
(input)	[Reaction:9012517] Pro-IL18 binds Caspase-1 tetramer [Homo sapiens] [BlackBoxEvent:9012520] IL18-2 binds 2x(CASP1(120-197):CASP1(317-404)) [Homo sapiens] [BlackBoxEvent:9012542] IL37 binds 2x(CASP1(120-197):CASP1(317-404)) [Homo sapiens] [Reaction:9731057] SARS-CoV-1 3a binds to caspase-1 [Homo sapiens]
(output)	[Reaction:448702] Caspase-1 active tetramer formation [Homo sapiens] [BlackBoxEvent:9012092] IL18 and IL18 propeptide dissociate from Caspase-1 tetramer [Homo sapiens] [BlackBoxEvent:9012500] IL18-2(1-36) and IL18-2(37-189) dissociates from IL18-2(1-36):IL18-2(37-189):2x(CASP1(120-197):CASP1(317-404)) [Homo sapiens] [BlackBoxEvent:9012689] IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) [Homo sapiens] [BlackBoxEvent:9712407] CASP1 is activated by autoproteolysis [Homo sapiens] [BlackBoxEvent:9735702] CASP1 autoproteolysis [Homo sapiens]
(physicalEntity)	[CatalystActivity:448682] cysteine-type endopeptidase activity of Caspase-1 tetramer [cytosol]
(updatedInstance)	[_UpdateTracker:9871626] Update Tracker - [Complex:448691] Caspase-1 tetramer [cytosol] - v40:[modifyName] [_UpdateTracker:9897858] Update Tracker - [Complex:448691] Caspase-1 tetramer [cytosol] - v62:[addName, updateContainedComponent] [_UpdateTracker:9898399] Update Tracker - [Complex:448691] Caspase-1 tetramer [cytosol] - v63:[modifyName]
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No pathways have been reviewed or authored by Caspase-1 tetramer [cytosol] (448691)