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Details on Person Pro-interleukin-1 beta (pro-IL1B) is the primary substrate o...
| Class:Id | Summation:448679 |
|---|---|
| _displayName | Pro-interleukin-1 beta (pro-IL1B) is the primary substrate o... |
| _timestamp | 2010-04-21 16:27:46 |
| created | [InstanceEdit:448681] Jupe, S, 2009-11-25 |
| literatureReference | [LiteratureReference:448684] Caspase-activation pathways in apoptosis and immunity |
| modified | [InstanceEdit:448729] Jupe, S, 2009-11-25 [InstanceEdit:507731] Jupe, S, 2010-02-08 [InstanceEdit:617369] Jupe, S, 2010-04-21 |
| text | Pro-interleukin-1 beta (pro-IL1B) is the primary substrate of caspase-1. IL1B production and processing is stimulated when pathogen-associated molecular patterns (PAMPs) such as bacterial LPS are detected by cells of the innate immune system, and in response to pro-inflammatory cytokines such as TNF. Detection of PAMPs by Toll receptors leads to rapid IL1 transcription/translation and subsequent processing by caspase-1 in macrophages and monocytes. Processing is triggered by the activation of members of the NLR family and their associated inflammasome complexes. IL1B lacks a signal peptide to direct it to the Golgi for subsequent secretion, so the mode of secretion is uncertain. Once secreted, IL1B binds membrane-bound IL1 receptors, followed by recruitment of the IL1 receptor accessory protein to form a high affinity receptor complex. Ligand induced receptor activation induces the intracellular association of a number of cytosolic adapter proteins triggering intracellular signal transduction. This series of steps facilitates the induction of nuclear factor-kappa B (NFkB) and mitogen-activated protein kinase (MAPK) activity, leading to downstream transcription of additional inflammatory cytokines, including IL1B itself. A calpain-like potease has been reported to be important for the processing of pro- IL1A, but much less is known about how IL1A is released from cells and what specific roles it plays in biology. |
| (summation) | [Reaction:448703] Interleukin-1 family precursors are cleaved by caspase-1 [Homo sapiens] |
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No pathways have been reviewed or authored by Pro-interleukin-1 beta (pro-IL1B) is the primary substrate o... (448679)
