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Details on Person Interleukin-35 translocates from the ER lumen to the extracellular region

Class:Id	BlackBoxEvent:448627
_displayName	Interleukin-35 translocates from the ER lumen to the extracellular region
_doRelease	TRUE
_timestamp	2017-05-24 16:06:31
authored	[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21 [InstanceEdit:448563] Jupe, S, 2009-11-25
compartment	[Compartment:984] extracellular region [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:448563] Jupe, S, 2009-11-25
edited	[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21
input	[Complex:8950589] IL12A:EBI3 [endoplasmic reticulum lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8949818] Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin [LiteratureReference:448574] IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells [LiteratureReference:6809130] The inhibitory cytokine IL-35 contributes to regulatory T-cell function [LiteratureReference:8981061] Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases
modified	[InstanceEdit:622266] Jupe, S, 2010-04-22 [InstanceEdit:6809137] Garapati, Phani Vijay, 2015-11-09 [InstanceEdit:6809167] Garapati, Phani Vijay, 2015-11-09 [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 [InstanceEdit:8981109] Duenas, Corina, 2017-03-01 [InstanceEdit:9006961] Jupe, Steve, 2017-05-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Interleukin-35 translocates from the ER lumen to the extracellular region IL12A:EBI3(IL35) are secreted to the extracellular medium
output	[Complex:622267] IL35 [extracellular region] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8950740] CANX dissociates from IL12A:EBI3 [Homo sapiens] [BlackBoxEvent:8950362] EBI3:CANX binds IL12A [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6809153] Narazaki, M, Tanaka, M, 2015-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812277] R-HSA-448627.4
summation	[Summation:6809146] Interleukin-35 heterodimer is formed by interleukin-12 alph...
(hasEvent)	[Pathway:8984722] Interleukin-35 Signalling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:6809140] IL35 binds IL-12RB2:IL6ST receptor [Homo sapiens] [BlackBoxEvent:8983518] IL35 binds IL6ST:IL6ST receptor [Homo sapiens] [BlackBoxEvent:8983519] IL35 binds IL12RB2:IL12RB2 receptor [Homo sapiens] [BlackBoxEvent:8984001] IL35 binds IL27RA:IL12RB2 receptor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781366] Update Tracker - [BlackBoxEvent:448627] Interleukin-35 translocates from the ER lumen to the extracellular region - v61:[modifyText] [_UpdateTracker:9781983] Update Tracker - [BlackBoxEvent:448627] Interleukin-35 translocates from the ER lumen to the extracellular region - v60:[addLiteratureReference, add_removeInput, modifyText]
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