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Details on Person Interleukin-1 receptor-like 1 (IL1RL1, ST2), known for many ...

Class:Id	Summation:448602
_displayName	Interleukin-1 receptor-like 1 (IL1RL1, ST2), known for many ...
_timestamp	2017-10-17 09:49:04
created	[InstanceEdit:448563] Jupe, S, 2009-11-25
literatureReference	[LiteratureReference:448595] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines [LiteratureReference:448624] IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex [LiteratureReference:8981672] Interleukin 33 is a guardian of barriers and a local alarmin [LiteratureReference:8981655] Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases [LiteratureReference:8981651] Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members [LiteratureReference:8981752] IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo [LiteratureReference:8981741] Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket [LiteratureReference:8981744] Special aspects of interleukin-33 and the IL-33 receptor complex [LiteratureReference:8981781] Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes
modified	[InstanceEdit:6803161] Jupe, Steve, 2015-10-05 [InstanceEdit:6804715] Jupe, Steve, 2015-10-14 [InstanceEdit:8854660] Jupe, Steve, 2016-01-28 [InstanceEdit:8981679] Jupe, Steve, 2017-03-13 [InstanceEdit:8981791] Jupe, Steve, 2017-03-14 [InstanceEdit:9012706] Duenas, Corina, 2017-07-18 [InstanceEdit:9017177] Duenas, Corina, 2017-08-17 [InstanceEdit:9024500] Duenas, Corina, 2017-10-05 [InstanceEdit:9024654] Duenas, Corina, 2017-10-06 [InstanceEdit:9026021] Jupe, Steve, 2017-10-17
text	Interleukin-1 receptor-like 1 (IL1RL1, ST2), known for many years to be an orphan receptor within the IL1 receptor family, can bind Interleukin-33 (IL33) (Schmitz et al. 2005). The functional IL33 receptor is a heteromeric receptor complex consisting of IL1RL1 and Interleukin-1 receptor accessory protein (IL1RAP1) (Chackerian et al. 2007, Lingel et al. 2009). IL33 is found constitutively in the nucleus of endothelial cells where it can bind histone H2A-H2B (Roussel et al. 2008) leading to poorly understood intracrine gene regulatory functions (Carriere et al. 2007, Martin et al. 2013). It can be passively released from damaged cells, hence it has been termed an alarmin or damage-associated molecular pattern (DAMP), though IL33 is also released by undamaged cells (Lefrancais & Cayrol 2012).
(summation)	[Reaction:448604] Il33 binds Interleukin-33 receptor [Mus musculus] [Reaction:448629] IL33 binds IL1RL1 [Homo sapiens]
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No pathways have been reviewed or authored by Interleukin-1 receptor-like 1 (IL1RL1, ST2), known for many ... (448602)