Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Interleukin-27 is a heterodimer composed of Interleukin-27 s...
| Class:Id | Summation:448470 |
|---|---|
| _displayName | Interleukin-27 is a heterodimer composed of Interleukin-27 s... |
| _timestamp | 2017-05-18 12:50:08 |
| created | [InstanceEdit:448455] Jupe, S, 2009-11-24 |
| literatureReference | [LiteratureReference:448414] WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 [LiteratureReference:8950167] IL-27 Promotes Proliferation of Human Leukemic Cell Lines Through the MAPK/ERK Signaling Pathway and Suppresses Sensitivity to Chemotherapeutic Drugs [LiteratureReference:8950538] A soluble form of IL-27Rα is a natural IL-27 antagonist |
| modified | [InstanceEdit:6804715] Jupe, Steve, 2015-10-14 [InstanceEdit:6809137] Garapati, Phani Vijay, 2015-11-09 [InstanceEdit:8951033] Duenas, Corina, 2016-12-02 [InstanceEdit:9006421] Duenas, Corina, 2017-05-16 [InstanceEdit:9006730] Duenas, Corina, 2017-05-18 |
| text | Interleukin-27 is a heterodimer composed of Interleukin-27 subunit alpha (IL27) and Epstein-Barr virus-induced gene 3 (EBI3). It binds to the Interleukin-27 heterodimeric receptor, which is composed of Interleukin-27 receptor subunit alpha (IL27RA, WSX-1) and Interleukin-6 receptor subunit beta (IL6ST, gp130). IL6ST is a signal transducing protein that is a component of several other cytokine receptors including the Interleukin-6 and Interleukin-11 receptors (Pflanz et al. 2004). In the absence of IL27RA, Interleukin-27 can bind to IL6ST but with low affinity (Jia et al. 2016). Regulation: IL27RA can be cleaved releasing a soluble form (sIL27RA) that can bind to Interleukin-27 and antagonize Interleukin-27 binding to its heterodimer receptor (Dietrich et al. 2014). |
| (summation) | [Reaction:448427] Interleukin-27 binds Interleukin-27 receptor [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Interleukin-27 is a heterodimer composed of Interleukin-27 s... (448470)
