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Details on Person Temporal models suggest that the first event in IL22 recepto...

Class:IdSummation:448448
_displayNameTemporal models suggest that the first event in IL22 recepto...
_timestamp2017-07-04 12:30:42
created[InstanceEdit:448455] Jupe, S, 2009-11-24
literatureReference[LiteratureReference:8854695] Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2
[LiteratureReference:8987011] Structure of IL-22 bound to its high-affinity IL-22R1 chain
[LiteratureReference:448435] Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
[LiteratureReference:448430] A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist
modified[InstanceEdit:448681] Jupe, S, 2009-11-25
[InstanceEdit:6804715] Jupe, Steve, 2015-10-14
[InstanceEdit:8854660] Jupe, Steve, 2016-01-28
[InstanceEdit:9005492] Duenas, Corina, 2017-05-09
[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009475] Duenas, Corina, 2017-06-19
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9010942] Duenas, Corina, 2017-06-28
[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
[InstanceEdit:9011698] Duenas, Corina, 2017-07-04
textTemporal models suggest that the first event in IL22 receptor formation is binding of Interleukin-22 (IL22) to IL22RA1), which pre associates with JAK1 (Li et al. 2004, Jones et al. 2008, Xie et al. 2000, Xu et al. 2001).
The Interleukin-22 receptor consists of IL22RA1 and Interleukin-10 receptor subunit beta (IL10RB), which is also a component of the receptors for Interleukin-10 (IL10), Interleukin-22 (IL22), Interleukin-26 (IL26), Interleukin-28 (IL28), and Interferon lambda-1 (IFNL1).
(summation)[Reaction:448480] IL22 binds IL22RA1:JAK1 receptor complex [Homo sapiens]
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