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Details on Person IL27:EBI3 [extracellular region]

Class:Id	Complex:448442
_displayName	IL27:EBI3 [extracellular region]
_timestamp	2016-12-02 11:08:50
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:448455] Jupe, S, 2009-11-24
hasComponent	[EntityWithAccessionedSequence:448466] IL27 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:448418] EBI3 [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:448474] IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells [LiteratureReference:8949818] Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
modified	[InstanceEdit:6787824] Jupe, Steve, 2015-07-17 [InstanceEdit:8950109] Duenas, Corina, 2016-12-02
name	IL27:EBI3 Interleukin-27
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6811921] R-HSA-448442.2
summation	[Summation:8950110] There is evidence that shows that when Interleukin-27 subuni...
(hasComponent)	[Complex:448431] IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] [Homo sapiens] [Complex:8950252] IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] [Homo sapiens] [Complex:8950331] IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] [Homo sapiens] [Complex:8952746] p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] [Homo sapiens]
(input)	[Reaction:448427] Interleukin-27 binds Interleukin-27 receptor [Homo sapiens]
(output)	[BlackBoxEvent:448421] Interleukin-27 translocates from the ER lumen to the extracellular region [Homo sapiens] [Reaction:8950210] Interleukin-27 dissociates from Interleukin-27 receptor [Homo sapiens]
(regulator)	[NegativeRegulation:8963601] Negative regulation by 'IL27:EBI3 [extracellular region]' [PositiveRegulation:8963604] Positive regulation by 'IL27:EBI3 [extracellular region]'
(updatedInstance)	[_UpdateTracker:9896581] Update Tracker - [Complex:448442] IL27:EBI3 [extracellular region] - v60:[addLiteratureReference, addSummation]
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No pathways have been reviewed or authored by IL27:EBI3 [extracellular region] (448442)