Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F

Class:Id	BlackBoxEvent:447246
_displayName	IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F
_doRelease	TRUE
_timestamp	2022-03-03 03:34:07
authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:447133] Jupe, S, 2009-11-20
edited	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
input	[DefinedSet:447091] IL17A dimer,IL17F dimer,IL17A:IL17F [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:447176] IL17RA [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:447216] IL17RC [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:447173] Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor [LiteratureReference:447188] IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding [LiteratureReference:447165] Cutting edge: interleukin 17 signals through a heteromeric receptor complex [LiteratureReference:448383] Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer
modified	[InstanceEdit:448382] Jupe, S, 2009-11-24 [InstanceEdit:448553] Jupe, S, 2009-11-25 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8854531] Jupe, Steve, 2016-01-27 [InstanceEdit:8854754] Jupe, Steve, 2016-01-28 [InstanceEdit:8951027] Duenas, Corina, 2016-12-02 [InstanceEdit:8979597] Duenas, Corina, 2017-02-27 [InstanceEdit:8983528] Jupe, Steve, 2017-03-24 [InstanceEdit:8983831] Duenas, Corina, 2017-03-29 [InstanceEdit:9016491] Duenas, Corina, 2017-08-14 [InstanceEdit:9765935] Shamovsky, Veronica, 2022-02-17 [InstanceEdit:9768017] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F
output	[Complex:448403] IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8951040] IL17A dimer translocates from cytosol to extracellular region [Homo sapiens] [BlackBoxEvent:8951054] IL17A:IL17F translocates from cytosol to extracellular region [Homo sapiens] [BlackBoxEvent:8951071] IL17F dimer translocates from cytosol to extracellular region [Homo sapiens]
regulatedBy	[PositiveRegulation:9765934] Positive regulation by '8:IL17RA [plasma membrane]'
regulationReference	[RegulationReference:9765929] Positive regulation by '8:IL17RA [extracellular region]' ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28 [InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861354] R-HSA-447246.6
summation	[Summation:447117] The Interleukin-17 receptor A/C complex is a dimer of Interl...
(hasEvent)	[Pathway:448424] Interleukin-17 signaling [Homo sapiens] [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens]
(precedingEvent)	[Reaction:8951104] TRAF3IP2 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774911] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v80:[addRegulator, modifyText] [_UpdateTracker:9780244] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v63:[modifyText] [_UpdateTracker:9780908] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v61:[modifyText] [_UpdateTracker:9781603] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v60:[add_removeInput, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (447246)