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Details on Person Interleukin-12 binds Interleukin-12 receptor

Class:IdReaction:447226
_displayNameInterleukin-12 binds Interleukin-12 receptor
_doReleaseTRUE
_timestamp2017-09-07 15:08:01
authored[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
[Compartment:70101] cytosol
created[InstanceEdit:447133] Jupe, S, 2009-11-20
edited[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
input[Complex:447102] IL12A:IL12B [extracellular region] [Homo sapiens]
[Complex:8950052] IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:8854478] Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130
[LiteratureReference:447201] Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12
[LiteratureReference:8854492] IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts
[LiteratureReference:447167] Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
[LiteratureReference:8950140] Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
modified[InstanceEdit:448681] Jupe, S, 2009-11-25
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8854506] Jupe, Steve, 2016-01-27
[InstanceEdit:8854754] Jupe, Steve, 2016-01-28
[InstanceEdit:8950119] Duenas, Corina, 2016-12-02
[InstanceEdit:9005964] Duenas, Corina, 2017-05-11
[InstanceEdit:9006072] Duenas, Corina, 2017-05-12
[InstanceEdit:9006961] Jupe, Steve, 2017-05-24
[InstanceEdit:9017557] Duenas, Corina, 2017-08-22
[InstanceEdit:9020592] Duenas, Corina, 2017-09-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameInterleukin-12 binds Interleukin-12 receptor
output[Complex:8950116] IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] [Homo sapiens]
regulatedBy[NegativeRegulation:8951201] Negative regulation by 'IL12B [extracellular region]'
[NegativeRegulation:8951224] Negative regulation by '2xIL12B [extracellular region]'
regulationReference[RegulationReference:9642270] Negative regulation by 'IL12B [extracellular region]' Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
[RegulationReference:9642815] Negative regulation by '2xIL12B [extracellular region]' Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8861352] R-HSA-447226.8
summation[Summation:447218] Interleukin-12 (IL12) is a heterodimer of interleukin 12 alp...
(hasEvent)[Pathway:9020591] Interleukin-12 signaling [Homo sapiens]
(precedingEvent)[BlackBoxEvent:8981094] Gene expression after IL12:IL12 receptor interaction [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781227] Update Tracker - [Reaction:447226] Interleukin-12 binds Interleukin-12 receptor - v61:[modifyText]
[_UpdateTracker:9781901] Update Tracker - [Reaction:447226] Interleukin-12 binds Interleukin-12 receptor - v60:[addLiteratureReference, addRegulator, add_removeInput, add_removeOutput, modifyText]
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