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Details on Person The Interleukin-17 receptor A/C complex is a dimer of Interl...

Class:IdSummation:447117
_displayNameThe Interleukin-17 receptor A/C complex is a dimer of Interl...
_timestamp2022-02-18 04:07:19
created[InstanceEdit:447133] Jupe, S, 2009-11-20
literatureReference[LiteratureReference:447173] Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
[LiteratureReference:447165] Cutting edge: interleukin 17 signals through a heteromeric receptor complex
[LiteratureReference:8951058] Crystal structures of interleukin 17A and its complex with IL-17 receptor A
[LiteratureReference:8979748] Structural basis of receptor sharing by interleukin 17 cytokines
[LiteratureReference:9755346] ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway
modified[InstanceEdit:448382] Jupe, S, 2009-11-24
[InstanceEdit:5678550] Jupe, Steve, 2015-02-24
[InstanceEdit:6804715] Jupe, Steve, 2015-10-14
[InstanceEdit:8850923] Jupe, Steve, 2016-01-04
[InstanceEdit:8854531] Jupe, Steve, 2016-01-27
[InstanceEdit:8979750] Duenas, Corina, 2017-02-27
[InstanceEdit:8983529] Jupe, Steve, 2017-03-24
[InstanceEdit:8983913] Jupe, Steve, 2017-03-31
[InstanceEdit:9024462] Duenas, Corina, 2017-10-04
[InstanceEdit:9766209] Shamovsky, Veronica, 2022-02-18
textThe Interleukin-17 receptor A/C complex is a dimer of Interleukin-17 receptor A (IL17RA) and Interleukin-17 receptor C (IL17RC). It binds interleukin-17A (IL17A) dimers, IL17F dimers and IL17A:IL17F heterodimers (IL17A:IL17F) (Yao et al. 1995, Toy et al. 2006). IL17A and IL17F homodimers tend to disfavor binding of a second molecule of IL17RA to the receptor/ligand complex (Liu et al. 2013). Engagement of IL17RA or IL17RC by IL17A or IL17F brings about an allosteric 'preference' for the second receptor-binding site to engage a different receptor to form a heterodimeric receptor complex (Ely et al. 2003) This is a Black Box event because the order of receptor binding is unclear.

Secreted SARS-CoV-2 ORF8 (8) binds to IL17RA and activates IL17 signaling pathway leading to an increased secretion of cytokines/chemokines thus contributing to cytokine storm during SARS-CoV-2 infection (Lin X et al. 2021).

(summation)[BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F [Homo sapiens]
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