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Details on Person IL12A:IL12B [extracellular region]

Class:Id	Complex:447102
_displayName	IL12A:IL12B [extracellular region]
_timestamp	2016-11-29 15:53:30
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:447133] Jupe, S, 2009-11-20
hasComponent	[EntityWithAccessionedSequence:447212] IL12A [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:447181] IL12B [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8949834] The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells
modified	[InstanceEdit:6787775] Jupe, Steve, 2015-07-17 [InstanceEdit:8854506] Jupe, Steve, 2016-01-27 [InstanceEdit:8866786] Jupe, Steve, 2016-04-04 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:8949833] Jupe, Steve, 2016-11-29
name	IL12A:IL12B IL12 Interleukin-12
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8872283] R-HSA-447102.4
(hasComponent)	[Complex:447090] IL12A:IL12B:2xIL12RB1 [plasma membrane] [Homo sapiens] [Complex:8950116] IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] [Homo sapiens] [Complex:8950227] IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] [Homo sapiens] [Complex:8950686] IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] [Homo sapiens] [Complex:8981056] IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [cytosol] [Homo sapiens]
(hasMember)	[DefinedSet:6789357] IL13-downregulated proteins [extracellular region] [Homo sapiens]
(input)	[Reaction:447226] Interleukin-12 binds Interleukin-12 receptor [Homo sapiens]
(output)	[Reaction:8950128] Interleukin-12 dissociates from Interleukin-12 receptor [Homo sapiens] [Reaction:8950347] IL12A:IL12B translocates from late endosome lumen to extracellular region [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9896256] Update Tracker - [Complex:447102] IL12A:IL12B [extracellular region] - v60:[addLiteratureReference]
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No pathways have been reviewed or authored by IL12A:IL12B [extracellular region] (447102)