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Details on Person IL6 [extracellular region]

Class:Id	EntityWithAccessionedSequence:447100
_displayName	IL6 [extracellular region]
_timestamp	2011-03-02 09:32:39
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:447133] Jupe, S, 2009-11-20
endCoordinate	212
modified	[InstanceEdit:449665] Jupe, S, 2009-12-03 [InstanceEdit:3448660] Wu, G, 2013-05-16
name	IL6 Interleukin-6 IL6_HUMAN
referenceEntity	[ReferenceGeneProduct:57279] UniProt:P05231 IL6 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1225500] R-HSA-447100.1
startCoordinate	30
(hasComponent)	[Complex:449985] IL6RA:IL6 [plasma membrane] [Homo sapiens] [Complex:1067638] IL6:IL6R [plasma membrane] [Homo sapiens] [Complex:1067687] IL6:IL6R-2 [extracellular region] [Homo sapiens]
(hasMember)	[DefinedSet:5432918] Pro-inflammatory cytokines and chemokines [Homo sapiens] [DefinedSet:6784987] IL10-downregulated extracellular proteins [extracellular region] [Homo sapiens] [DefinedSet:6789485] IL4,IL13-downregulated extracellular proteins [extracellular region] [Homo sapiens] [DefinedSet:6790034] STAT3-upregulated extracellular proteins [extracellular region] [Homo sapiens] [DefinedSet:9662737] Glucocorticoid, IL6, IL10 [extracellular region] [Homo sapiens]
(input)	[Reaction:449994] Interleukin-6 receptor alpha subunit binds interleukin-6 [Homo sapiens] [Reaction:1067640] IL6 binds IL6R-2 [Homo sapiens] [Reaction:1067667] IL6 binds IL6R [Homo sapiens]
(output)	[BlackBoxEvent:3790130] Regulation of IL6 transcription [Homo sapiens] [BlackBoxEvent:9662710] IL6 gene produces IL6 protein [Homo sapiens] [BlackBoxEvent:9958875] NFκB stimulates IL6 gene expression [Homo sapiens]
(regulator)	[PositiveRegulation:8961338] Positive regulation by 'IL6 [extracellular region]' [PositiveGeneExpressionRegulation:9662898] Positive gene expression regulation by 'IL6 [extracellular region]'
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No pathways have been reviewed or authored by IL6 [extracellular region] (447100)