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Details on Person AMPK phosphorylates Raptor in the mTORC1 complex

Class:Id	Reaction:447074
_displayName	AMPK phosphorylates Raptor in the mTORC1 complex
_doRelease	TRUE
_timestamp	2015-05-14 15:44:07
authored	[InstanceEdit:500330] Katajisto, P, Makela, T, Wu, J, 2010-02-03
catalystActivity	[CatalystActivity:381847] AMP-activated protein kinase activity of p-AMPK heterotrimer:AMP [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:447077] Jassal, Bijay, 2009-11-20
edited	[InstanceEdit:447077] Jassal, Bijay, 2009-11-20
input	[Complex:165678] Active mTORC1 complex [lysosomal membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:447068] AMPK phosphorylation of raptor mediates a metabolic checkpoint
modified	[InstanceEdit:449022] Jassal, B, 2009-11-27 [InstanceEdit:500332] Jassal, B, 2010-02-03 [InstanceEdit:3006723] Jassal, B, 2013-02-01 [InstanceEdit:3132777] Jassal, Bijay, 2013-02-13 [InstanceEdit:5672806] Jupe, Steve, 2015-02-06 [InstanceEdit:5673770] Jupe, Steve, 2015-02-10 [InstanceEdit:5687546] Jupe, Steve, 2015-04-08 [InstanceEdit:5687631] Jupe, Steve, 2015-04-08 [InstanceEdit:5693184] Jupe, Steve, 2015-05-14 [InstanceEdit:5693285] Jupe, Steve, 2015-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AMPK phosphorylates Raptor in the mTORC1 complex
output	[Complex:5693284] mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:380930] Phosphorylated AMPK binds AMP [Homo sapiens] [Reaction:200421] Activation of cytosolic AMPK by phosphorylation [Homo sapiens]
releaseDate	2010-03-16
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105369] R-HSA-447074.2
summation	[Summation:447071] Activated AMPK (phosphorylated on Thr172 or Thr174 and AMP b...
(hasEvent)	[Pathway:380972] Energy dependent regulation of mTOR by LKB1-AMPK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784602] Update Tracker - [Reaction:447074] AMPK phosphorylates Raptor in the mTORC1 complex - v53:[add_removeOutput] [_UpdateTracker:9784915] Update Tracker - [Reaction:447074] AMPK phosphorylates Raptor in the mTORC1 complex - v52:[add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9788063] Update Tracker - [Reaction:447074] AMPK phosphorylates Raptor in the mTORC1 complex - v44:[add_removeInput, add_removeOutput]
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