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Details on Person TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...

Class:IdSummation:447018
_displayNameTAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
_timestamp2021-08-18 15:28:21
created[InstanceEdit:447015] Jupe, S, 2009-11-19
literatureReference[LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
[LiteratureReference:9685225] SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6
modified[InstanceEdit:447020] Jupe, S, 2009-11-19
[InstanceEdit:450149] Jupe, S, 2009-12-16
[InstanceEdit:450189] Jupe, S, 2009-12-16
[InstanceEdit:622269] Jupe, S, 2010-04-22
[InstanceEdit:975771] Shamovsky, V, 2010-10-04
[InstanceEdit:2586668] Shamovsky, V, 2012-11-16
[InstanceEdit:9710983] Shamovsky, Veronica, 2021-01-06
[InstanceEdit:9711028] Shamovsky, Veronica, 2021-01-07
[InstanceEdit:9713621] Shamovsky, Veronica, 2021-01-27
[InstanceEdit:9751145] Shamovsky, Veronica, 2021-08-18
textTAK1-binding protein 2 (TAB2) and/or TAB3, as part of a complex that also contains TAK1 and TAB1, binds polyubiquitinated TRAF6. The TAB2 and TAB3 regulatory subunits of the TAK1 complex contain C-terminal Npl4 zinc finger (NZF) motifs that recognize with Lys63-pUb chains (Kanayama et al. 2004). The recognition mechanism is specific for Lys63-linked ubiquitin chains (Kulathu Y et al 2009). TAK1 can be activated by unattached Lys63-polyubiquitinated chains when TRAF6 has no detectable polyubiquitination (Xia et al. 2009) and thus the synthesis of these chains by TRAF6 may be the signal transduction mechanism.

As a de-ubiquitinating/de-ISGylating enzyme, severe acute respiratory syndrome coronavirus type 1 (SARS-CoV-1) 1a-encoded papain-like protease (PLPro or nsp3) antagonizes the host type I interferon (IFN) response by removing Lys63-linked ubiquitin chains of TRAF3 and TRAF6 (Li SW et al. 2016).

(summation)[Reaction:446870] Polyubiquitinated TRAF6 binds the TAK1 complex [Homo sapiens]
[Reaction:936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens]
[Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex [Homo sapiens]
[Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation [Homo sapiens]
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