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Details on Person IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4

Class:Id	Reaction:446648
_displayName	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4
_doRelease	TRUE
_timestamp	2017-09-11 14:10:55
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:446650] Jupe, S, 2009-11-16
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
input	[Complex:450120] IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:166081] IRAK4 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:446683] Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4 [LiteratureReference:446653] Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components
modified	[InstanceEdit:450128] Jupe, S, 2009-12-14 [InstanceEdit:507710] Jupe, S, 2010-02-08 [InstanceEdit:744684] Jupe, S, 2010-05-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9020703] Jupe, Steve, 2017-09-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4
output	[Complex:446637] IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105861] R-HSA-446648.3
summation	[Summation:446640] MYD88 is a cytoplasmic adaptor protein that is recruited to ...
(hasEvent)	[Pathway:9020702] Interleukin-1 signaling [Homo sapiens]
(normalReaction)	[FailedReaction:5602413] Defective MyD88 does not form complex with IRAK4 in IL1R signaling [Homo sapiens] [FailedReaction:5602583] IRAK4 deficiency blocks the formation of MyD88-IRAK4 Myddosome in IL1R pathway [Homo sapiens] [FailedReaction:5602684] Defective IRAK4 does not form complex with MyD88 within TLR7/8 complex [Homo sapiens]
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No pathways have been reviewed or authored by IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (446648)