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Details on Person IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]

Class:Id	Complex:446643
_displayName	IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]
_timestamp	2017-07-13 16:41:20
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:446650] Jupe, S, 2009-11-16
hasComponent	[Complex:445758] IL1R1:IL1:IL1RAP [plasma membrane] [Homo sapiens] [Complex:445755] IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:197595] IL1R1 [plasma membrane] [Homo sapiens] [DefinedSet:445744] IL1B,Myr82K-Myr83K-IL1A [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:445745] IL1RAP-1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:446649] p-T342,T345,S346-IRAK4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:446885] TOLLIP [cytosol] [Homo sapiens] [Complex:193932] MYD88 dimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:446679] Jupe, S, 2009-11-16 [InstanceEdit:446872] Jupe, S, 2009-11-18 [InstanceEdit:622266] Jupe, S, 2010-04-22 [InstanceEdit:9012434] Duenas, Corina, 2017-07-13
name	IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP IL1 receptor complex - activated IRAK4:TOLLIP
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1112176] R-HSA-446643.2
(hasComponent)	[Complex:446689] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] [Homo sapiens] [Complex:446693] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] [Homo sapiens] [Complex:446696] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] [Homo sapiens]
(input)	[BlackBoxEvent:446684] IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation [Homo sapiens] [Reaction:446692] IRAK1 binds to MYD88 within the IL1R complex [Homo sapiens]
(output)	[Reaction:446634] IRAK4 is activated by autophosphorylation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9892951] Update Tracker - [Complex:446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] - v54:[updateContainedComponent] [_UpdateTracker:9897393] Update Tracker - [Complex:446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] - v62:[addName, updateContainedComponent] [_UpdateTracker:9902995] Update Tracker - [Complex:446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] - v80:[updateContainedComponent]
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No pathways have been reviewed or authored by IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (446643)