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Details on Person IRAK4 is activated by autophosphorylation

Class:Id	Reaction:446634
_displayName	IRAK4 is activated by autophosphorylation
_doRelease	TRUE
_timestamp	2017-09-11 14:11:16
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:446650] Jupe, S, 2009-11-16
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
input	[Complex:446888] IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:446630] Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop
modified	[InstanceEdit:446872] Jupe, S, 2009-11-18 [InstanceEdit:744684] Jupe, S, 2010-05-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9020703] Jupe, Steve, 2017-09-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK4 is activated by autophosphorylation
output	[Complex:446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2010-06-15
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104448] R-HSA-446634.3
summation	[Summation:446631] IRAK4 is activated by autophosphorylation at 3 positions wit...
(hasEvent)	[Pathway:9020702] Interleukin-1 signaling [Homo sapiens]
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No pathways have been reviewed or authored by IRAK4 is activated by autophosphorylation (446634)