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Details on Person The human gene SLC18A1 encodes vesicular amine transporter 1...
| Class:Id | Summation:446284 |
|---|---|
| _displayName | The human gene SLC18A1 encodes vesicular amine transporter 1... |
| _timestamp | 2009-11-12 13:21:25 |
| created | [InstanceEdit:446281] Jassal, Bijay, 2009-11-12 |
| text | The human gene SLC18A1 encodes vesicular amine transporter 1, VMAT1. It is expressed as integral proteins of the membrane of secretory vesicles in neuronal and endocrine cells. VMAT1 mediates the transport of biogenic amines into secretory vesicles (Erickson JD et al, 1996), which then discharge them into the extracellular space by exocytosis. The process requires an exchange for a proton for each monoamine neurotransmitter. Predominant substrates are serotonin (5HT), dopamine, adrenaline, noradrenaline and histamine. VMAT1 is expressed in the adrenal gland, sympathetic ganglia, skin and GI tract. |
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