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Details on Person Downregulation of MAP kinases by MAPK phosphatases

Class:Id	Reaction:446241
_displayName	Downregulation of MAP kinases by MAPK phosphatases
_doRelease	FALSE
_timestamp	2016-07-15 23:50:22
authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
catalystActivity	[CatalystActivity:446238] MAP kinase tyrosine/serine/threonine phosphatase activity of MAPK phosphatases [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:446232] Shamovsky, V, 2009-11-11
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
inferredFrom	[Reaction:203797] ERKs are inactivated by dual-specific phosphatases (DUSPs) [Homo sapiens]
input	[DefinedSet:442890] phosphorylated MAP kinases_p38_JNK_ERK1/2 [nucleoplasm] [Gallus gallus] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm]
literatureReference	[LiteratureReference:202675] A module of negative feedback regulators defines growth factor signaling [LiteratureReference:433834] Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss [LiteratureReference:433995] In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs)
modified	[InstanceEdit:451543] Shamovsky, V, 2010-01-05 [InstanceEdit:573301] Shamovsky, V, 2010-04-09 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1063713] Shamovsky, V, 2010-11-25 [InstanceEdit:1094881] Shamovsky, V, 2010-11-29 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Downregulation of MAP kinases by MAPK phosphatases
output	[DefinedSet:446235] MAP kinases_p38_JNK_ERK1/2 [nucleoplasm] [Gallus gallus] [SimpleEntity:113550] Pi [nucleoplasm] [SimpleEntity:113550] Pi [nucleoplasm]
precedingEvent	[Reaction:438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 [Gallus gallus] [Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus [Gallus gallus] [Reaction:437995] Activated JNK migrates to the nucleoplasm [Gallus gallus] [Reaction:438005] MKK4 phosphorylates JNK [Gallus gallus]
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:8918790] R-GGA-446241.1
(hasEvent)	[Pathway:451524] MAPK activation in TLR cascade [Gallus gallus]
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No pathways have been reviewed or authored by Downregulation of MAP kinases by MAPK phosphatases (446241)