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Details on Person Addition of a second mannose to the N-glycan precursor by ALG2

Class:Id	Reaction:446208
_displayName	Addition of a second mannose to the N-glycan precursor by ALG2
_doRelease	TRUE
_timestamp	2010-12-02 14:39:51
authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449272] alpha-1,3-mannosyltransferase activity of ALG2 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
figure	[Figure:975560] /figures/4_GlcNAc2Man2PPDol.png
input	[SimpleEntity:449283] MDCDD [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:162860] GDP-Man [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:449330] A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis
modified	[InstanceEdit:449318] Jassal, B, 2009-12-02 [InstanceEdit:449347] Jassal, B, 2009-12-02 [InstanceEdit:449736] Jassal, B, 2009-12-07 [InstanceEdit:749517] Jassal, B, 2010-05-19 [InstanceEdit:916859] Jassal, B, 2010-07-29 [InstanceEdit:936934] Jassal, B, 2010-08-24 [InstanceEdit:938684] Jassal, B, 2010-08-31 [InstanceEdit:975558] Jassal, B, 2010-09-29 [InstanceEdit:1022125] Jassal, B, 2010-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Addition of a second mannose to the N-glycan precursor by ALG2
output	[SimpleEntity:449737] (GlcNAc)2 (Man)2 (PP-Dol)1 [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:446218] Addition of the first mannose to the N-glycan precursor by ALG1 [Homo sapiens] [Reaction:446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105542] R-HSA-446208.2
summation	[Summation:446213] A second mannose is added to the N-glycan precursor via an a...
(hasEvent)	[Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein [Homo sapiens]
(normalReaction)	[FailedReaction:4549368] Defective ALG2 does not transfer a second Man to N-glycan precursor [Homo sapiens]
(precedingEvent)	[Reaction:449718] Addition of a third mannose to the N-glycan precursor by ALG2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786877] Update Tracker - [Reaction:446208] Addition of a second mannose to the N-glycan precursor by ALG2 - v47:[modifyText] [_UpdateTracker:9790227] Update Tracker - [Reaction:446208] Addition of a second mannose to the N-glycan precursor by ALG2 - v34:[modifyText]
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