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Details on Person ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP

Class:Id	Reaction:446207
_displayName	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP
_doRelease	TRUE
_timestamp	2014-11-07 15:22:46
authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449313] N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity of ALG13:ALG14 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
figure	[Figure:975569] /figures/2_GlcNAc2PPDol.png
input	[SimpleEntity:449222] GlcNAcDOLDP [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:162756] UDP-GlcNAc [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:449340] Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation
modified	[InstanceEdit:449318] Jassal, B, 2009-12-02 [InstanceEdit:449347] Jassal, B, 2009-12-02 [InstanceEdit:749517] Jassal, B, 2010-05-19 [InstanceEdit:916859] Jassal, B, 2010-07-29 [InstanceEdit:936928] Jassal, B, 2010-08-24 [InstanceEdit:975558] Jassal, B, 2010-09-29 [InstanceEdit:1022125] Jassal, B, 2010-11-17 [InstanceEdit:5633234] Jassal, Bijay, 2014-10-31 [InstanceEdit:5635727] Matthews, Lisa, 2014-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP Addition of the second N-acetyl-glucosamine to the N-glycan precursor
output	[SimpleEntity:110096] UDP [cytosol] [SimpleEntity:449293] N,N'-DCDOLDP [cytoplasmic side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:446191] Addition of N-acetyl-D-glucosamine to Dolichyl phosphate [Homo sapiens] [Reaction:446200] DOLPP1 dephosphorylates DOLDP to DOLP [Homo sapiens] [Reaction:446204] GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine [Homo sapiens] [Reaction:446195] DOLK phosphorylates DCHOL to DOLP [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104858] R-HSA-446207.2
summation	[Summation:446220] A second N-acetylglucosamine is added to the N-glycan precur...
systematicName	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP
(hasEvent)	[Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein [Homo sapiens]
(normalReaction)	[FailedReaction:5633241] Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP [Homo sapiens]
(precedingEvent)	[Reaction:446218] Addition of the first mannose to the N-glycan precursor by ALG1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790206] Update Tracker - [Reaction:446207] ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP - v34:[modifyText]
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No pathways have been reviewed or authored by ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (446207)