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Details on Person Addition of the first glucose to the N-glycan precursor by ALG6

Class:Id	Reaction:446202
_displayName	Addition of the first glucose to the N-glycan precursor by ALG6
_doRelease	TRUE
_timestamp	2016-09-23 17:28:21
authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449636] dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity of ALG6 [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
figure	[Figure:975557] /figures/13_Glc1GlcNAc2Man9PPDol.png
input	[SimpleEntity:449371] (GlcNAc)2 (Man)9 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:532542] DbGP [lumenal side of endoplasmic reticulum membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:449643] A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic [LiteratureReference:449898] Clinical and molecular characterization of the first adult congenital disorder of glycosylation (CDG) type Ic patient
modified	[InstanceEdit:449648] Jassal, B, 2009-12-02 [InstanceEdit:449659] Jassal, B, 2009-12-03 [InstanceEdit:449893] Jassal, B, 2009-12-09 [InstanceEdit:749517] Jassal, B, 2010-05-19 [InstanceEdit:913606] Jassal, B, 2010-07-19 [InstanceEdit:916859] Jassal, B, 2010-07-29 [InstanceEdit:937272] Jassal, B, 2010-08-25 [InstanceEdit:975558] Jassal, B, 2010-09-29 [InstanceEdit:1022125] Jassal, B, 2010-11-17 [InstanceEdit:8940167] D'Eustachio, Peter, 2016-09-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Addition of the first glucose to the N-glycan precursor by ALG6
output	[SimpleEntity:449649] (Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:449311] DOLP [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 [Homo sapiens] [Reaction:446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104778] R-HSA-446202.3
summation	[Summation:446190] The first glucose is added to the N-glycan precursor, mediat...
(hasEvent)	[Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein [Homo sapiens]
(normalReaction)	[FailedReaction:4724291] Defective ALG6 does not add glucose to the N-glycan precursor [Homo sapiens]
(precedingEvent)	[Reaction:446189] Addition of a second glucose to the N-glycan precursor by ALG8 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782564] Update Tracker - [Reaction:446202] Addition of the first glucose to the N-glycan precursor by ALG6 - v59:[add_removeLiteratureReference] [_UpdateTracker:9790252] Update Tracker - [Reaction:446202] Addition of the first glucose to the N-glycan precursor by ALG6 - v34:[add_removeInput]
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