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Details on Person PMM1,2 isomerise Man6P to Man1P

Class:Id	Reaction:446201
_displayName	PMM1,2 isomerise Man6P to Man1P
_doRelease	TRUE
_timestamp	2025-11-04 21:50:04
authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:532558] phosphomannomutase activity of PMM1,2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9909220] phosphomannomutase activity of PMM1,2 [cytosol] The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
crossReference	[DatabaseIdentifier:9909217] RHEA:11142
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
input	[SimpleEntity:532562] Man6P [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:532524] PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized on chromosome 22q13 [LiteratureReference:532526] Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome) [LiteratureReference:9909215] The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a [LiteratureReference:532561] Isolation of the human phosphomannomutase gene (PMM1) and assignment to chromosome 22q13
modified	[InstanceEdit:449347] Jassal, B, 2009-12-02 [InstanceEdit:532517] Jassal, B, 2010-03-01 [InstanceEdit:532665] Jassal, B, 2010-03-02 [InstanceEdit:749517] Jassal, B, 2010-05-19 [InstanceEdit:1022125] Jassal, B, 2010-11-17 [InstanceEdit:3781827] Jassal, B, 2013-06-28 [InstanceEdit:5690643] Jassal, Bijay, 2015-04-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9909224] D'Eustachio, Peter, 2024-04-30 [InstanceEdit:9910565] D'Eustachio, Peter, 2024-05-15 [InstanceEdit:9971186] D'Eustachio, Peter, 2025-11-04
name	PMM1,2 isomerise Man6P to Man1P D-mannose 6-phosphate => alpha-D-mannose 1-phosphate Mannose 6-phosphate isomerises to Mannose 1-phosphate
output	[SimpleEntity:532531] Man1P [cytosol]
precedingEvent	[Reaction:9909159] HK1 phosphorylates Mannose to Man6P [Homo sapiens] [Reaction:429567] Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 [Homo sapiens] [Reaction:8876283] SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol [Homo sapiens] [Reaction:532549] MPI isomerises Fru6P to Man6P [Homo sapiens] [Reaction:70471] GPI dimer isomerizes G6P [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16 [InstanceEdit:9910566] Hill, David P, 2024-05-15
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9909260] D'Eustachio, Peter, 2024-05-01
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105822] R-HSA-446201.4
summation	[Summation:532568] Cytosolic phosphomannomutases 1 and 2 (PMM1 and PMM2) cataly...
(hasEvent)	[Pathway:446205] Synthesis of GDP-mannose [Homo sapiens]
(normalReaction)	[FailedReaction:3781926] Defective PMM2 does not isomerise Man6P to Man1P [Homo sapiens]
(precedingEvent)	[Reaction:446221] GMPPB converts Mannose-1-phosphate to GDP-Mannose [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784776] Update Tracker - [Reaction:446201] PMM1,2 isomerise Man6P to Man1P - v53:[modifyText] [_UpdateTracker:9787181] Update Tracker - [Reaction:446201] PMM1,2 isomerise Man6P to Man1P - v46:[modifyText] [_UpdateTracker:9790285] Update Tracker - [Reaction:446201] PMM1,2 isomerise Man6P to Man1P - v34:[modifyText] [_UpdateTracker:9911092] Update Tracker - [Reaction:446201] PMM1,2 isomerise Man6P to Man1P - v89:[addLiteratureReference, modifyText]
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