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Details on Person The precursor of the N-glycan sugar, now in the form of (Glc...
| Class:Id | Summation:446196 |
|---|---|
| _displayName | The precursor of the N-glycan sugar, now in the form of (Glc... |
| _timestamp | 2013-09-23 08:03:03 |
| created | [InstanceEdit:446206] Jassal, B, 2009-11-10 |
| modified | [InstanceEdit:449318] Jassal, B, 2009-12-02 [InstanceEdit:449736] Jassal, B, 2009-12-07 [InstanceEdit:604389] Jassal, B, 2010-04-16 [InstanceEdit:772532] Jassal, B, 2010-05-21 [InstanceEdit:933769] Jassal, B, 2010-08-17 [InstanceEdit:4570574] Jassal, B, 2013-09-23 |
| text | The precursor of the N-glycan sugar, now in the form of (GlcNAc)2 (Man)5 (PP-Dol), is flipped across the ER membrane, moving it from the cytosolic side into the ER lumen. The exact mechanism of this translocation is not well understood: the protein RFT1 is known to be involved (Helenius et al. 2002), along with an unknown flippase, which is distinct from the one that flips the Dol-P linked precursors (Dol-P-Mannose and Dol-P-glucose) (Sanyal et al. 2008). Defects in RFT1 are associated with Congenital Disorder of Glycosylation 1N (CDG1N) (Haeuptle et al. 2008). |
| (summation) | [Reaction:446212] Flipping of the N-glycan precursor to inside the ER [Homo sapiens] |
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No pathways have been reviewed or authored by The precursor of the N-glycan sugar, now in the form of (Glc... (446196)
