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Details on Person ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1

Class:IdReaction:446188
_displayNameALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1
_doReleaseTRUE
_timestamp2018-01-29 10:21:46
authored[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity[CatalystActivity:449317] alpha-1,3-mannosyltransferase activity of ALG3 [endoplasmic reticulum membrane]
compartment[Compartment:17957] endoplasmic reticulum lumen
created[InstanceEdit:446206] Jassal, B, 2009-11-10
edited[InstanceEdit:446206] Jassal, B, 2009-11-10
figure[Figure:975562] /figures/9_GlcNAc2Man6PPDol.png
input[SimpleEntity:449298] (GlcNAc)2 (Man)5 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane]
[SimpleEntity:449229] DOLP-Man [lumenal side of endoplasmic reticulum membrane]
isChimericFALSE
literatureReference[LiteratureReference:449316] Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia
[LiteratureReference:449896] Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate
modified[InstanceEdit:449318] Jassal, B, 2009-12-02
[InstanceEdit:449347] Jassal, B, 2009-12-02
[InstanceEdit:449893] Jassal, B, 2009-12-09
[InstanceEdit:749517] Jassal, B, 2010-05-19
[InstanceEdit:916859] Jassal, B, 2010-07-29
[InstanceEdit:937272] Jassal, B, 2010-08-25
[InstanceEdit:975558] Jassal, B, 2010-09-29
[InstanceEdit:1022125] Jassal, B, 2010-11-17
[InstanceEdit:5633234] Jassal, Bijay, 2014-10-31
[InstanceEdit:9036029] Jassal, Bijay, 2018-01-29
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1
Addition of the sixth mannose to the N-glycan precursor by ALG3
output[SimpleEntity:449315] (GlcNAc)2 (Man)6 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane]
[SimpleEntity:449311] DOLP [lumenal side of endoplasmic reticulum membrane]
precedingEvent
regulatedBy[PositiveRegulation:4628424] Positive regulation by 'MPDU1 [endoplasmic reticulum membrane]'
releaseDate2010-06-15
reviewed[InstanceEdit:749519] Gagneux, P, 2010-04-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105810] R-HSA-446188.4
summation[Summation:449261] The sixth mannose is added to the N-glycan precursor. This r...
(hasEvent)[Pathway:446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein [Homo sapiens]
(normalReaction)[FailedReaction:4720473] Defective ALG3 does not add mannose to the N-glycan precursor [Homo sapiens]
[FailedReaction:9036025] Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3 [Homo sapiens]
(precedingEvent)[Reaction:446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786881] Update Tracker - [Reaction:446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - v47:[addRegulator, modifyText]
[_UpdateTracker:9790232] Update Tracker - [Reaction:446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - v34:[modifyText]
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No pathways have been reviewed or authored by ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (446188)
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