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Details on Person The actin-binding domain of plectin interacts with the first...
| Class:Id | Summation:446047 |
|---|---|
| _displayName | The actin-binding domain of plectin interacts with the first... |
| _timestamp | 2009-11-17 06:43:21 |
| created | [InstanceEdit:446058] Matthews, L, 2009-11-09 |
| literatureReference | [LiteratureReference:446044] Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding [LiteratureReference:446042] A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells [LiteratureReference:446053] Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes |
| modified | [InstanceEdit:446092] Matthews, L, 2009-11-09 [InstanceEdit:446714] Matthews, L, 2009-11-17 |
| text | The actin-binding domain of plectin interacts with the first pair of FNIII repeats and the N-terminal 35 amino acids of the connecting segment of integrin b4 ( Geerts et al., 1999; Niessen et al., 1997; Koster et al., 2004). This interaction is thought to be the initial step in hemidesmosome (HD) assembly and is critical for the mechanical stability of the HD. This interaction is destabilized when HD disassembly is required, for example, to allow cell migration during wound healing. The Integrin a6b4 also associates extracellularly with laminin-332 (See Koster et al., 2003). |
| (summation) | [Reaction:432909] Interaction of Plectin with Integrin beta 4 [Homo sapiens] |
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No pathways have been reviewed or authored by The actin-binding domain of plectin interacts with the first... (446047)
