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Details on Person Phosphorylation of Smooth Muscle Myosin Light Chains

Class:Id	Reaction:445813
_displayName	Phosphorylation of Smooth Muscle Myosin Light Chains
_doRelease	TRUE
_timestamp	2018-09-20 14:22:55
authored	[InstanceEdit:446860] Gillespie, ME, 2009-11-18
catalystActivity	[CatalystActivity:445811] myosin light chain kinase activity of MYLK:Ca2+:CALM1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:445812] Gillespie, ME, 2009-11-05
edited	[InstanceEdit:446860] Gillespie, ME, 2009-11-18
input	[DefinedSet:445793] Smooth Muscle Myosin Light Chain [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:445784] Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells [LiteratureReference:445761] Isoforms of myosin and actin in human, monkey and rat myometrium. Comparison of pregnant and non-pregnant uterus proteins [LiteratureReference:445796] The distribution of heavy-chain isoforms of myosin in airways smooth muscle from adult and neonate humans
modified	[InstanceEdit:445823] Gillespie, ME, 2009-11-05 [InstanceEdit:446730] Gillespie, ME, 2009-11-17 [InstanceEdit:447013] Gillespie, ME, 2009-11-19 [InstanceEdit:2656454] D'Eustachio, P, 2012-11-23 [InstanceEdit:9620125] Jassal, Bijay, 2018-09-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of Smooth Muscle Myosin Light Chains
output	[DefinedSet:445770] Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:445797] MYLK (MLCK) Active Calmodulin Binding [Homo sapiens] [Reaction:74448] Calcium binds calmodulin [Homo sapiens]
regulatedBy	[NegativeRegulation:9620126] Negative regulation by 'cGMP [cytosol]' [PositiveRegulation:9034487] Positive regulation by 'CALM1:4xCa2+ [cytosol]'
releaseDate	2009-12-15
reviewed	[InstanceEdit:165091] Rush, MG, 2008-01-11 00:00:00
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105712] R-HSA-445813.3
summation	[Summation:445819] The smooth muscle light chain kinase phosphorylates the smoo...
(hasEvent)	[Pathway:445355] Smooth Muscle Contraction [Homo sapiens]
(precedingEvent)	[Reaction:445705] Release Of ADP From Myosin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778907] Update Tracker - [Reaction:445813] Phosphorylation of Smooth Muscle Myosin Light Chains - v67:[addRegulator]
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No pathways have been reviewed or authored by Phosphorylation of Smooth Muscle Myosin Light Chains (445813)