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Details on Person IL1B,Myr82K-Myr83K-IL1A:IL1R1

Class:IdReaction:445753
_displayNameIL1B,Myr82K-Myr83K-IL1A:IL1R1
_doReleaseTRUE
_timestamp2020-06-02 10:05:24
authored[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:445754] Jupe, S, 2009-11-05
edited[InstanceEdit:744683] Jupe, S, 2010-05-17
input[EntityWithAccessionedSequence:197595] IL1R1 [plasma membrane] [Homo sapiens]
[DefinedSet:445744] IL1B,Myr82K-Myr83K-IL1A [extracellular region] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:446131] Interleukin 1 signaling occurs exclusively via the type I receptor
[LiteratureReference:8942533] The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical
modified[InstanceEdit:446142] Jupe, S, 2009-11-09
[InstanceEdit:617369] Jupe, S, 2010-04-21
[InstanceEdit:744684] Jupe, S, 2010-05-17
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8942532] Jupe, Steve, 2016-10-17
[InstanceEdit:9012434] Duenas, Corina, 2017-07-13
[InstanceEdit:9690514] Jassal, Bijay, 2020-06-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameIL1B,Myr82K-Myr83K-IL1A:IL1R1
Interleukin-1 receptor type 1 binds Interleukin 1
output[Complex:445755] IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9690516] Negative regulation by 'IL1R1:IL1R1 inhibitors [plasma membrane]'
regulationReference[RegulationReference:9690519] Negative regulation by 'IL1R1:IL1R1 inhibitors [plasma membrane]' Multicenter Study of a Novel Topical Interleukin-1 Receptor Inhibitor, Isunakinra, in Subjects With Moderate to Severe Dry Eye Disease
releaseDate2010-06-15
reviewed[InstanceEdit:744680] Pinteaux, E, 2010-05-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105054] R-HSA-445753.5
summation[Summation:445749] Interleukin-1 receptor type 1 (IL1R1) is the receptor respon...
(hasEvent)[Pathway:9020702] Interleukin-1 signaling [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776805] Update Tracker - [Reaction:445753] IL1B,Myr82K-Myr83K-IL1A:IL1R1 - v74:[addRegulator]
[_UpdateTracker:9782388] Update Tracker - [Reaction:445753] IL1B,Myr82K-Myr83K-IL1A:IL1R1 - v59:[addLiteratureReference]
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No pathways have been reviewed or authored by IL1B,Myr82K-Myr83K-IL1A:IL1R1 (445753)