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Details on Person Direct identification of prohormone conversion site in insulin-secreting cells
| Class:Id | LiteratureReference:445479 |
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| _displayName | Direct identification of prohormone conversion site in insulin-secreting cells |
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| _timestamp | 2009-10-31 07:57:08 |
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| author | [Person:159003] Orci, L
[Person:264354] Ravazzola, M
[Person:445498] Amherdt, M
[Person:445530] Madsen, O
[Person:159007] Vassalli, JD
[Person:445519] Perrelet, A |
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| created | [InstanceEdit:445524] May, B, 2009-10-31 |
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| journal | Cell |
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| modified | [InstanceEdit:445578] May, B, 2009-10-31 |
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| pages | 671-81 |
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| pubMedIdentifier | 3896518 |
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| title | Direct identification of prohormone conversion site in insulin-secreting cells |
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| volume | 42 |
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| year | 1985 |
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| (literatureReference) | [BlackBoxEvent:265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi [Homo sapiens]
[BlackBoxEvent:265153] Proinsulin:Zinc:Calcium complex translocates to immature secretory granule [Homo sapiens]
[Reaction:9023159] Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87)) [Homo sapiens]
[Reaction:9023163] Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) [Homo sapiens]
[Reaction:9023178] PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) [Homo sapiens]
[Reaction:9023196] PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) [Homo sapiens] |
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