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Details on Person UniProt:P67811 SEC11A
| Class:Id | ReferenceGeneProduct:445319 |
|---|---|
| _chainChangeLog | chain:1-179 added on Sat February 7 2015 |
| _displayName | UniProt:P67811 SEC11A |
| _timestamp | 2024-08-09 20:01:36 |
| chain | chain:1-179 |
| checksum | DFD245A17BA3B47F |
| comment | FUNCTION Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:14559916, PubMed:3511473, PubMed:8444896). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).CATALYTIC ACTIVITY Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.SUBUNIT Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SPCS2 and SPCS3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).SUBCELLULAR LOCATION The C-terminal short (CTS) helix is essential for catalytic activity (By similarity). It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates (By similarity).SIMILARITY Belongs to the peptidase S26B family. |
| created | [InstanceEdit:445298] May, B, 2009-10-29 |
| description | recommendedName: Signal peptidase complex catalytic subunit SEC11A ecNumber evidence="3 4"3.4.21.89 alternativeName: Endopeptidase SP18 alternativeName: Microsomal signal peptidase 18 kDa subunit shortName: SPase 18 kDa subunit alternativeName: SEC11 homolog A alternativeName: SEC11-like protein 1 alternativeName: SPC18 |
| geneName | SEC11A SEC11L1 SPC18 |
| identifier | P67811 |
| isSequenceChanged | FALSE |
| keyword | Direct protein sequencing Endoplasmic reticulum Hydrolase Membrane Protease Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:445324] May, B, 2009-10-29 [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | SEC11A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SC11A_CANLF O75957 P21378 |
| sequenceLength | 179 |
| species | [Species:49646] Canis familiaris |
| (referenceEntity) | [EntityWithAccessionedSequence:445308] SC11A_CANFA [endoplasmic reticulum membrane] [Canis familiaris] |
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No pathways have been reviewed or authored by UniProt:P67811 SEC11A (445319)
