Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q28250 SPCS2
| Class:Id | ReferenceGeneProduct:445315 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-226 added on Sat February 7 2015;initiator methionine:1 for 445315 removed on Fri Nov 03 2023;initiator methionine: for 445315 added on Fri Nov 03 2023;initiator methionine: for 445315 removed on Fri Aug 15 2025;initiator methionine:1 for 445315 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q28250 SPCS2 |
| _timestamp | 2025-08-15 21:11:21 |
| chain | initiator methionine:1 chain:2-226 |
| checksum | 85830E5484593176 |
| comment | FUNCTION Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).SUBUNIT Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SEC11A or SEC11C and SPCS1 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).SUBCELLULAR LOCATION Belongs to the SPCS2 family. |
| created | [InstanceEdit:445298] May, B, 2009-10-29 |
| description | recommendedName: Signal peptidase complex subunit 2 alternativeName: Microsomal signal peptidase 25 kDa subunit shortName: SPase 25 kDa subunit |
| geneName | SPCS2 SPC25 |
| identifier | Q28250 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Direct protein sequencing Endoplasmic reticulum Membrane Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:445324] May, B, 2009-10-29 [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SPCS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SPCS2_CANLF |
| sequenceLength | 226 |
| species | [Species:49646] Canis familiaris |
| (referenceEntity) | [EntityWithAccessionedSequence:445295] SPCS2_CANFA [endoplasmic reticulum membrane] [Canis familiaris] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q28250 SPCS2 (445315)
