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Details on Person Signal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin

Class:IdReaction:445309
_displayNameSignal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin
_doReleaseTRUE
_timestamp2026-05-09 17:39:23
authored[InstanceEdit:445291] May, B, 2009-10-29
catalystActivity[CatalystActivity:445314] serine-type endopeptidase activity of Signal Peptidase Complex (Canis familiaris) [endoplasmic reticulum membrane]
catalystActivityReference[CatalystActivityReference:9643235] serine-type endopeptidase activity of Signal Peptidase Complex (Canis familiaris) [endoplasmic reticulum membrane] Purification of microsomal signal peptidase as a complex
compartment[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:445298] May, B, 2009-10-29
edited[InstanceEdit:445291] May, B, 2009-10-29
input[EntityWithAccessionedSequence:445269] Preprolactin (bovine) [endoplasmic reticulum membrane] [Bos taurus]
isChimericTRUE
literatureReference[LiteratureReference:445307] Purification of microsomal signal peptidase as a complex
[LiteratureReference:9988652] Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity
modified[InstanceEdit:445324] May, B, 2009-10-29
[InstanceEdit:5251722] May, B, 2014-02-04
[InstanceEdit:8936028] May, Bruce, 2016-08-16
[InstanceEdit:8936036] May, Bruce, 2016-08-16
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9988655] May, Bruce, 2026-05-09
nameSignal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin
output[EntityWithAccessionedSequence:445294] Prolactin (Bos taurus) [endoplasmic reticulum lumen] [Bos taurus]
releaseDate2009-12-15
reviewed[InstanceEdit:445291] May, B, 2009-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48898] Bos taurus
[Species:49646] Canis familiaris
stableIdentifier[StableIdentifier:1105951] R-NUL-445309.4
summation[Summation:445303] The signal peptide is cleaved by the signal peptidase comple...
(inferredFrom)[Reaction:400459] Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 [Homo sapiens]
[Reaction:400496] Signal peptidase hydrolyzes preproGIP to proGIP [Homo sapiens]
[Reaction:934647] Cleavage of the Signal Peptide of Preprolactin [Homo sapiens]
[Reaction:1799329] Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein [Homo sapiens]
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