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Details on Person UniProt:P83362 SPCS1
| Class:Id | ReferenceGeneProduct:445305 |
|---|---|
| _chainChangeLog | chain:1- added on Fri February 6 2015;chain:1-39 for 445305 removed on Wed May 4 2022;chain:1-102 for 445305 added on Wed May 4 2022 |
| _displayName | UniProt:P83362 SPCS1 |
| _timestamp | 2023-11-03 17:34:38 |
| chain | chain:1-102 |
| checksum | EB12830247E532A7 |
| comment | FUNCTION Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473). Dispensable for SPC enzymatic activity (By similarity).SUBUNIT Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SPCS2 and SPCS3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).SUBCELLULAR LOCATION Expressed in the pancreas (at protein level).PTM May be phosphorylated.SIMILARITY Belongs to the SPCS1 family. |
| created | [InstanceEdit:445298] May, B, 2009-10-29 |
| description | recommendedName: Signal peptidase complex subunit 1 alternativeName: Microsomal signal peptidase 12 kDa subunit shortName: SPase 12 kDa subunit |
| geneName | SPCS1 SPC12 |
| identifier | P83362 |
| isSequenceChanged | FALSE |
| keyword | Direct protein sequencing Endoplasmic reticulum Membrane Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:445324] May, B, 2009-10-29 [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9796771] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | SPCS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SPCS1_CANLF F6V6C9 |
| sequenceLength | 102 |
| species | [Species:49646] Canis familiaris |
| (referenceEntity) | [EntityWithAccessionedSequence:445316] SPCS1_CANFA [endoplasmic reticulum membrane] [Canis familiaris] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P83362 SPCS1 (445305)
