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Details on Person UniProt:P61008 SPCS3
| Class:Id | ReferenceGeneProduct:445304 |
|---|---|
| _chainChangeLog | chain:1-180 added on Fri February 6 2015 |
| _displayName | UniProt:P61008 SPCS3 |
| _timestamp | 2023-11-03 15:40:59 |
| chain | chain:1-180 |
| checksum | 342AB8E0F3F6D71A |
| comment | FUNCTION Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473, PubMed:8444896). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).SUBUNIT Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SEC11A or SEC11C and SPCS1 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).SUBCELLULAR LOCATION Occurs in 2 differentially glycosylated forms (22 kDa and 23 kDa).SIMILARITY Belongs to the SPCS3 family. |
| created | [InstanceEdit:445298] May, B, 2009-10-29 |
| description | recommendedName: Signal peptidase complex subunit 3 alternativeName: Microsomal signal peptidase 22/23 kDa subunit shortName: SPC22/23 shortName: SPase 22/23 kDa subunit |
| geneName | SPCS3 SPC22 |
| identifier | P61008 |
| isSequenceChanged | FALSE |
| keyword | Direct protein sequencing Endoplasmic reticulum Glycoprotein Membrane Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:445324] May, B, 2009-10-29 [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | SPCS3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SPCS3_CANLF P12280 Q9H0S7 |
| sequenceLength | 180 |
| species | [Species:49646] Canis familiaris |
| (referenceEntity) | [EntityWithAccessionedSequence:445301] SPCS3_CANFA [endoplasmic reticulum membrane] [Canis familiaris] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P61008 SPCS3 (445304)
