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Details on Person The heterotrimer of SEC61-alpha, SEC61-beta, and SEC61-gamma...
| Class:Id | Summation:445285 |
|---|---|
| _displayName | The heterotrimer of SEC61-alpha, SEC61-beta, and SEC61-gamma... |
| _timestamp | 2026-05-12 17:12:19 |
| created | [InstanceEdit:445274] May, B, 2009-10-29 |
| literatureReference | [LiteratureReference:9986943] Structure of the Sec61 channel opened by a signal sequence |
| modified | [InstanceEdit:445291] May, B, 2009-10-29 [InstanceEdit:9988772] May, Bruce, 2026-05-12 [InstanceEdit:9988773] May, Bruce, 2026-05-12 |
| text | The heterotrimer of SEC61-alpha, SEC61-beta, and SEC61-gamma form a single channel called the translocon that spans the endoplasmic reticulum membrane and is able to transport a nascent peptide from the cytosol to the endoplasmic reticulum lumen (Görlich et al. 1992, Görlich and Rapoport 1993, Hartmann et al. 1994, Snapp et al. 2004, Kalies et al. 2008, Gogala et al. 2008). The reaction described here contains a preprotein from Bos taurus and translocon complexes from Canis familiaris and was demonstrated in vitro. Entry of the signal sequence opens the central channel of the Sec61 complex to initiate translocation (Voorhees and Hegde 2016). The translocon is part of a larger complex that contains the translocon-associated (TRAP) complex and may contain the oligosaccharyltransferase (OST) complex. |
| (summation) | [Reaction:445275] Translocon (canine) binds Preprolactin (bovine) [Bos taurus] [Reaction:9988757] Sec61 translocon (canine) translocates Preprolactin (bovine) [Bos taurus] |
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No pathways have been reviewed or authored by The heterotrimer of SEC61-alpha, SEC61-beta, and SEC61-gamma... (445285)
