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Details on Person UniProt:P38377 SEC61A1
| Class:Id | ReferenceGeneProduct:445282 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-476 added on Sat February 7 2015;initiator methionine:1 for 445282 removed on Fri Nov 03 2023;initiator methionine: for 445282 added on Fri Nov 03 2023;initiator methionine: for 445282 removed on Fri Aug 15 2025;initiator methionine:1 for 445282 added on Fri Aug 15 2025 |
| _displayName | UniProt:P38377 SEC61A1 |
| _timestamp | 2025-08-15 22:04:11 |
| chain | initiator methionine:1 chain:2-476 |
| checksum | B1A9B7A6697327FE |
| comment | FUNCTION Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:10799540, PubMed:1423609). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:36261528). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).SUBUNIT The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:10799540, PubMed:1423609, PubMed:36261528). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:36261528).INTERACTION Localizes exclusively in granular structures in the endoplasmic reticulum (ER).SIMILARITY Belongs to the SecY/SEC61-alpha family. |
| created | [InstanceEdit:445274] May, B, 2009-10-29 |
| description | recommendedName: Protein transport protein Sec61 subunit alpha isoform 1 shortName: Sec61 alpha-1 |
| geneName | SEC61A1 |
| identifier | P38377 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Developmental protein Direct protein sequencing Endoplasmic reticulum Membrane Protein transport Reference proteome Translocation Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:445291] May, B, 2009-10-29 [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SEC61A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | S61A1_CANLF |
| sequenceLength | 476 |
| species | [Species:49646] Canis familiaris |
| (referenceEntity) | [EntityWithAccessionedSequence:445272] S61A1_CANFA [endoplasmic reticulum membrane] [Canis familiaris] |
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No pathways have been reviewed or authored by UniProt:P38377 SEC61A1 (445282)
