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Details on Person UniProt:P60467 SEC61B
| Class:Id | ReferenceGeneProduct:445279 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-96 added on Fri February 6 2015;initiator methionine:1 for 445279 removed on Fri Nov 03 2023;initiator methionine: for 445279 added on Fri Nov 03 2023;initiator methionine: for 445279 removed on Fri Aug 15 2025;initiator methionine:1 for 445279 added on Fri Aug 15 2025 |
| _displayName | UniProt:P60467 SEC61B |
| _timestamp | 2025-08-15 21:10:59 |
| chain | initiator methionine:1 chain:2-96 |
| checksum | 5FAFF4197A62FA49 |
| comment | FUNCTION Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:8107851). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:8107851). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:36261528). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).SUBUNIT The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:10799540, PubMed:10860986, PubMed:36261528, PubMed:8107851). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:36261528). Interacts with TRAM1 (By similarity).SUBCELLULAR LOCATION Belongs to the SEC61-beta family. |
| created | [InstanceEdit:445274] May, B, 2009-10-29 |
| description | recommendedName: Protein transport protein Sec61 subunit beta |
| geneName | SEC61B |
| identifier | P60467 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Endoplasmic reticulum Lipoprotein Membrane Palmitate Phosphoprotein Protein transport Reference proteome Translocation Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:445291] May, B, 2009-10-29 [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SEC61B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SC61B_CANLF P38390 P38391 |
| sequenceLength | 96 |
| species | [Species:49646] Canis familiaris |
| (referenceEntity) | [EntityWithAccessionedSequence:445271] SC61B_CANFA [endoplasmic reticulum membrane] [Canis familiaris] |
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No pathways have been reviewed or authored by UniProt:P60467 SEC61B (445279)
