Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P06625 SRPRA
| Class:Id | ReferenceGeneProduct:445206 |
|---|---|
| _chainChangeLog | chain:1-638 added on Fri February 6 2015 |
| _displayName | UniProt:P06625 SRPRA |
| _timestamp | 2023-11-03 16:48:01 |
| chain | chain:1-638 |
| checksum | AD88CE554ACC2BC6 |
| comment | FUNCTION Component of the SRP (signal recognition particle) receptor (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).SUBUNIT Heterodimer with SRPRB (By similarity). Interacts with the signal recognition particle (SRP) complex subunit SRP54 (By similarity).SUBCELLULAR LOCATION Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.DOMAIN The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the signal recognition particle (SRP) complex subunit SRP54 (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). GTPase induced rearrangement of SR drives SRP-mediated cotranslational protein translocation into the ER (By similarity).SIMILARITY Belongs to the GTP-binding SRP family. |
| created | [InstanceEdit:445185] May, B, 2009-10-29 |
| description | recommendedName: Signal recognition particle receptor subunit alpha shortName: SR-alpha alternativeName: Docking protein alpha shortName: DP-alpha |
| geneName | SRPRA SRPR |
| identifier | P06625 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum GTP-binding Membrane Nucleotide-binding Phosphoprotein Receptor Reference proteome |
| modified | [InstanceEdit:445291] May, B, 2009-10-29 [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | SRPRA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SRPRA_CANLF |
| sequenceLength | 638 |
| species | [Species:49646] Canis familiaris |
| (referenceEntity) | [EntityWithAccessionedSequence:445190] SRPR_CANFA [endoplasmic reticulum membrane] [Canis familiaris] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P06625 SRPRA (445206)
