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Details on Person UniProt:P33731 SRP72
| Class:Id | ReferenceGeneProduct:445201 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-671 added on Sat February 7 2015;initiator methionine:1 for 445201 removed on Fri Nov 03 2023;initiator methionine: for 445201 added on Fri Nov 03 2023;initiator methionine: for 445201 removed on Fri Aug 15 2025;initiator methionine:1 for 445201 added on Fri Aug 15 2025 |
| _displayName | UniProt:P33731 SRP72 |
| _timestamp | 2025-08-15 21:34:13 |
| chain | initiator methionine:1 chain:2-671 |
| checksum | E490121DAA76959F |
| comment | FUNCTION Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6413076). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:6413076). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:6413076, PubMed:8388879). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).SUBUNIT Heterodimer with SRP68 (PubMed:6413076, PubMed:8388879). SRP68-SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (PubMed:6413076, PubMed:8388879). Component of a signal recognition particle consisting of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6413076, PubMed:6938958). Within the SRP complex, interacts with SRP68 (via C-terminus) (PubMed:6413076, PubMed:8388879).SUBCELLULAR LOCATION Belongs to the SRP72 family. |
| created | [InstanceEdit:445185] May, B, 2009-10-29 |
| description | recommendedName: Signal recognition particle subunit SRP72 shortName: SRP72 alternativeName: Signal recognition particle 72 kDa protein |
| geneName | SRP72 |
| identifier | P33731 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Direct protein sequencing Endoplasmic reticulum Isopeptide bond Phosphoprotein Reference proteome Repeat Ribonucleoprotein Signal recognition particle TPR repeat Ubl conjugation |
| modified | [InstanceEdit:445291] May, B, 2009-10-29 [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SRP72 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SRP72_CANLF |
| sequenceLength | 671 |
| species | [Species:49646] Canis familiaris |
| (referenceEntity) | [EntityWithAccessionedSequence:445189] SRP72_CANFA [cytosol] [Canis familiaris] |
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No pathways have been reviewed or authored by UniProt:P33731 SRP72 (445201)
